Insulin-like growth factor-1 Long R3 (IGF-1 LR3) is a modified version of the naturally occurring insulin-like growth factor-1 (IGF-1). It is a synthetic peptide hormone that has been shown to have anabolic effects on muscle tissue, meaning it helps promote muscle growth and repair. IGF-1 LR3 differs from regular IGF-1 in that it has an additional 13 amino acids on its N-terminal end, which increases its half-life and bioavailability in the body. This makes it more effective at promoting muscle growth than regular IGF-1.
IGF-1 LR3 has a molecular weight of 9,200 Daltons and a molecular structure that is similar to insulin. It is composed of 83 amino acids, with an additional 13 amino acids at the N-terminal end compared to regular IGF-1. The addition of these amino acids increases the half-life of the hormone, allowing it to remain active in the body for longer periods of time.
Effects
IGF-1 LR3 is a popular supplement that has been shown to help individuals build muscle. It works by increasing the levels of insulin-like growth factor in the body, which helps to promote cell growth and division. This supplement has become increasingly popular among athletes and bodybuilders due to its ability to increase muscle mass and improve recovery time after workouts.
Some other benefits:
- Muscle hypertrophy effects
- Conserves muscle in heifers
- Increase lean muscle mass
- Improve athletic performance
- Improve muscle recovery after workouts
- Reduce recovery time after injuries
- Boost muscle protein synthesis
- Reduce Body Fat
- Facilitates protein synthesis in the body.
- Regulates the storage of fat and channels it to be used for the production of energy.
- Increases metabolism
- Increases the regenerative properties of the bodyās nerve tissues.
- Upregulates anti-oxidant benefit and ligament strength
Doses
Typically it is supplied in 500 mcg or 1000 mcg per vial.
Dosage suggestion from studies agree to inject 20-50 mcg SQ/IM daily for a max of 6-7 weeks. Dosing from 50 - 80 mcg can also be used with caution and under the supervision of a physician. Muscle pain can occur with higher dosing.
Desensitization can and does occur around 6 weeks after initial time of use. It is recommended to take 20-40 days off prior to starting another course of IGF1/LR3 again .
Some physicians suggest consuming protein with a blend of simple & complex carbohydrates 15-20 minutes prior to administering IGF-1/ LR3. Other recommend taking the medication before bed because that is when your body naturally replenishes its own growth hormone.
Cycles
On workout days, the injection should be administered pre and post-workout. On non-workout days, however, it can be administered at any time of day. Administering it at the same time every day Is highly recommended.Ā
A dosage cycle will typically run for 2 to 12 weeks. It is advisable to start with a lower dosage and then add as time goes by. Bodybuilders and those not known to IGF-1 have no problem being on the high dosage side of life. If IGF-1 is administered to you to treat deficiencies, do not hesitate to see your doctor if you have any questions or concerns.
If IGF-1 levels are too high or too low at the end of the dosage cycle, you can adjust the dosage levels accordingly depending on what problem you are trying to solve. Always stay within the reference range and consider your age, fitness level, and other factors before deciding on a dosage.

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